CHE326 Biochemistry: Nucleic Acids and Molecular Biology

Textbook: Essentials of Molecular Biology, Third Edition (1998) Malacinski and Freifelder

Course description and learning outcomes: This course is designed as an intermediate-level exploration of the structure and function of nucleic acids. This is a biochemistry course and thus the emphasis will be on the molecular interactions and reactions that result in the processing of genetic information. Specifically, by the end of this course you should understand:

· The molecular structure of DNA and RNAs

· How DNA in a cell is packaged, replicated, transcribed, translated, damaged and repaired

· How gene activity is regulated in both prokaryotes and eukaryotes

· The experimental manipulation of genetic information (genetic engineering)

In addition, your participation in this course will contribute to five areas that the College has defined as critical learning outcomes for a general education:

· Literature research for your student presentation will increase your literacy in information technology

· Finding solutions to homework problems and on essay-style exams will train you to think critically and creatively, and require you to communicate effectively in writing

· Student presentations are intended to teach students how to present scientific information and will foster effective oral communication

· You will enhance your appreciation of both the complexity and beauty of the natural world

 

Tentative Lecture Schedule

Week

1

2


3

4


5

6

7

8


9


10

11

12


13

14

15

16

Chapter

A portion of Chapter 2
Chapter 3

Chapter 3
Chapter 5

Chapter 6


Chapter 7
Exam 1

Chapter 8

Chapter 9

Chapter 10

Chapter 10
Exam 2

Chapter 11
Chapter 12

Chapter 13

Chapter 13

Chapter 14
Exam 3

Chapter 15

 

 

Final Exam

Subject

Nucleic Acid Structure

Nucleic Acid Structure (con't)
Higher Structures of Nucleic Acids

DNA as the Genetic Material:
An Introduction to DNA Function

DNA Replication
Chapters 2, 3, 5, 6 and 7

Transcription

Translation

Mutations, Mutagenesis, and DNA Repair

Mutations, Mutagenesis and Repair (con't)
Chapters 8, 9 and 10

Regulation of Gene Activity in Prokaryotes
Bacteriophage

Regulation of Gene Activity in Eukaryotes

Gene Activity in Eukaryotes (con't)

Plasmids and Transposons
Chapters 11, 12, 13 and 14

Recombinant DNA and Genetic Engineering

Research Presentations

Research Presentations and Summary

Comprehensive